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Research at the intersection of marine natural products
Research at the intersection of marine natural products
and neurotherapeutic drug discovery.
and neurotherapeutic drug discovery.
The overarching themes of the Avalon Lab are (1) Discovering Natural Product Neurotherapeutics, (2) Exploring Chemical Ecology in Marine Environments, and (3) Driving Fundamental Scientific Knowledge. The four pillars of the group reflect ways the research is framed: Isolation and Structure Elucidation, Genome Mining, Genetic Engineering, and Host-Microbial Interactions.
Each of these represent emerging areas with opportunities to explore uncharted biochemical space through development of innovative tools for targeted genome mining, omic explorations of marine invertebrate holobiomes, and heterologous expression of cryptic gene clusters with combinatorial biosynthesis.
Projects in the Avalon Lab
Neurotherapeutic Drug Discovery through Pharmacophore-Based Genome Mining
Invertebrate Host-Microbial Interactions: Leveraging Chemical Ecology for Neurotherapeutic Drug Discovery
Cerebrospinal Fluid Metabolomics Following Subarachnoid Hemorrhage
Restoration of Cerebral Metal Homeostasis through Cyanobacterial Metallophore Discovery
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